Side Effects:

Common Abdominal pain, Constipation, Diarrhoea, Epigastric pain, Flatulence, Nausea, Vomiting, Indigestion.

Expert advice for Pirox Capsule
Inform your doctor if you have ever been diagnosed with kidney or liver problems. It should be taken with food or milk to avoid getting an upset stomach. It can cause serious complications like stomach bleeding and kidney problems if taken for a long time. Pirox can raise your risk of blood clots, heart attack, or a stroke. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Frequently Asked Questions

Q. What is the difference between Pirox and diclofenac?
Both Pirox and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Pirox.

Q. What is the difference between Pirox and naproxen?
Both Pirox and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Pirox.

Q. What is the difference between Pirox and meloxicam?
Both Pirox and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Pirox.

Q. What is the difference between Pirox and ketoprofen?
Both Pirox and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Pirox. Ketoprofen gel also showed excellent tolerability.

Q. What is the difference between Pirox and tramadol?
Pirox is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

Q. What is the difference between Pirox and nimesulide?
Both Pirox and nimesulide are pain killers. However, Pirox is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Q. Can Pirox be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Pirox or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Pirox.

Q. Are Pirox and aspirin same?
No. Pirox and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Q. Can Pirox be used along with dexamethasone?
No. Pirox should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Q. Can Pirox be used with methocarbamol?
Yes. Methocarbamol can be used with Pirox as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Can Pirox be used along with paracetamol?
Yes. Paracetamol can be used with Pirox as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Is Pirox a NSAID?
Yes. Pirox is a non-steroidal anti-inflammatory drug (NSAID).

Q. Is Pirox a sulfa drug?
Pirox is a sulphur containing compound. Pirox can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Q. Is Pirox a blood thinner?
No. Pirox is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Q. Is Pirox a muscle relaxant?
No. Pirox is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Q. Is Pirox a narcotic?
No. Pirox is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Q. Can Pirox be used in hypertension?
No. Pirox is not a medication to control hypertension. It is important to note that Pirox decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Pirox.

Q. Can Pirox be used along with Losartan?
No. Pirox should not be combined with Losartan. It is important to note that Pirox decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pirox.

Q. Can Pirox be used with Lisinopril?
No. Pirox should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pirox.

Q. Can Pirox be used with calcium channel blocker?
Yes. Pirox can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Q. Can Pirox be used with Tizanidine?
Yes, Pirox can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Q. Why is beta cyclodextrin added to Pirox?
Yes. Pirox can be combined with beta-cyclodextrin. Research has shown that combining Pirox with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Q. Are there any alternatives of Pirox?
Yes. There are alternatives to Pirox. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Q. What are the contraindications for Pirox?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Q. Can Pirox be used in the treatment of allergy?
No. Pirox is not a drug to treat allergy. It is a pain killer.

Q. How long does Pirox work?
Pirox is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Q. Can you get high by using Pirox?
No. Pirox is not known to cause high. It is a non-narcotic painkiller.

Q. Can Pirox be used to treat menstrual cramp?
Pirox is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Q. Can I use Pirox for a migraine?
Pirox is not approved for the treatment of migraine. Research studies have shown that Pirox is effective in significantly decreasing the pain associated with migraine without aura.

Q. Is Pirox effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Pirox as the cause of back pain can be different for different person.

Q. Is Pirox affective in gout management?
Yes. Pirox can be given for the treatment of acute gout. Research studies have shown Pirox to be highly effective in the treatment of acute gout.

Q. Can you donate blood when on the medication with Pirox?
Yes. You can donate blood when on Pirox. Do inform your doctor before donating blood.

Q. Can I use Pirox if I am a diabetic?
Pirox in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Pirox so taking piroxicam can lead to increased risk of renal failure by many folds.

Q. Can I use Pirox if I have a deranged renal function?
No. Pirox should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Q. Can Pirox lead to skin reactions?
Yes. Pirox is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Q. Can I use Pirox if I am pregnant?
No. Pirox should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Q. Can I use Pirox if I have peptic ulcer disease?
No. Pirox is contraindicated in cases of active peptic ulcer disease. Pirox is known to cause gastric ulceration and bleeding.

Q. Can I use Pirox if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Q. Can Pirox lead to difficulty in conception?
Yes. Pirox can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Q. Can Pirox be used with diuretics?
No. Pirox should not be used with diuretics. Pirox reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Q. Can Pirox be used with lithium?
No. Pirox should not be used with lithium. Pirox leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Q. Can Pirox be used with warfarin?
No. Pirox should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Q. What increases the chances of getting a gastric ulcer when I am already taking Pirox?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Pirox?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Q. What are the serious side effects of Pirox?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.